Keywords: Phantoms, Quantitative Imaging, Reproducibility
Motivation: Variability and bias of diffusion parameters need to be assessed to separate the measurement-induced variability from biological effects.
Goal(s): Our goal was to assess the bias and variability of mean diffusivity (MD) from the Diffusion Tensor Model using a traceable phantom.
Approach: The NIST/QIBA phantom was scanned multiple times using two different head coils on the same system. The differences between MD measured using different head coils and bias to NIST-reported values were investigated.
Results: A significant difference in measured MD with two coils can be found across multiple vials. Both coils introduce non-negligible bias to NIST-reported values for lower MD values.
Impact: Using traceable phantoms is essential in the development of Diffusion MRI-based Quantitative Imaging Biomarkers (QIBs). Different head coils can introduce significant differences across MD values and should be treated as confounding factors in QIBs studies.
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