Keywords: Biomarkers, Traumatic brain injury
Motivation: Imaging biomarkers accurately diagnosing and monitoring treatment response for chronic mild Traumatic Brain Injury (mTBI) are needed.
Goal(s): This study aimed to experimentally validate and determine the performance of MRI biomarkers for monitoring chronic repetitive mild traumatic brain injury (mTBI).
Approach: We used diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) to assess white matter injury in mouse brains with chronic mTBI and compared results with those for age-matched control brains.
Results: Reduction in fractional anisotropy and increase of axial kurtosis were observed in the medulla of mTBI brains compared to the parameters in the same region of control brains.
Impact: It is new to monitor DTI and DKI parameters as noninvasive biomarkers in the brain with chronic mTBI.
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