Abstract #4922

Improvement of Glymphatic System Using Low-Intensity Focused Ultrasound (LIFU) for Lymphatic Enhancement

Hyochul Lee^1,2, Taekyu Jang^1,2, Ok kyu Park^2,3, Taewon Choi⁴, Seoyun Chang⁴, Jinhyoung Park⁴, and Seung Hong Choi^1,2,3

¹Interdisciplinary Program in Cancer, Seoul National University, Seoul, Korea, Republic of, ²Department of Radiology, Seoul National University Hospital, Seoul, Korea, Republic of, ³Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, Korea, Republic of, ⁴Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Gyeonggi-do, Korea, Republic of

Synopsis

Keywords: Neurofluids, Brain, Glymphatic system, Low-Intensity Focused Ultrasound, Lymphatic Enhancement, Contrast-enhanced MRI

Motivation: Enhanced lymphatic flow may improve the glymphatic system for metabolic waste clearance from the brain.

Goal(s): Our goal was to demonstrate that stimulating the lymphatics can enhance the glymphatic system.

Approach: We introduced low-intensity focused ultrasound (LIFU) to enhance the lymphatics and assessed the glymphatic system in rats by visualizing signal changes in contrast-enhanced MRI.

Results: The LIFU group exhibited a more rapid increase and decrease in signal intensity compared to the control group.

Impact: Lymphatic enhancement using LIFU could influence the improvement of the glymphatic system. This enhancement could positively affect cognitive function, with potential implications for preventing and treating neurodegenerative diseases.

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