Keywords: Bone, Diabetes
Motivation: Bone marrow is a key target for diabetes mellitus.
Goal(s): Quantitative assessment of fat content in lumbar bone marrow and trabecular microstructural changes in alloxan-induced diabetics rabbits.
Approach: Iterative decomposition of water and fat with echo asymmetry and least-squares estimation quantitation sequence (IDEAL-IQ), micro computed tomography (Micro-CT), and gas chromatography-mass spectrometry (GC-MS) were employed.
Results: IDEAL-IQ and GC-MS techniques are capable of detecting changes in fat content and variations in fatty acid composition during the early stages of diabetic bone marrow.
Impact: The fat content and fatty acid composition in the bone marrow plays an important role in bone metabolism in diabetic patients.
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