Keywords: Tumors (Pre-Treatment), Tumor, DCE-MRI, IDH, Glioma, P53, CDKN2A/B
Motivation: IDH, P53 and CDKN2A/2B are key molecular markers for adult diffuse gliomas.
Goal(s): This study aimed to compare values of conventional and advanced tracer kinetic models based on dynamic contrast enhanced (DCE)-MRI in predicting IDH, P53 and CDKN2A/B status in glioma patinets.
Approach: Patients diagnosed as adult diffuse gliomas were examined using dynamic contrast-enhanced MRI. Imaging data were analyzed using tracer kinetic models.
Results: Extofts model attained best performance in predicting IDH mutation.ATH model attained best performance in predicting P53 mutation. DP model attained best performance in predicting CDKN2A/B homozygous deletion.
Impact: Different Tracer Kinetic Models have illustrated excellent performance in predicting different molecular markers in glioma patients.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords