Abstract #0005

3D MR fingerprinting for dynamic contrast-enhanced imaging of whole mouse brain

Yuran Zhu¹, Guanhua Wang², Yuning Gu¹, Walter Zhao¹, Jiahao Lu¹, Junqing Zhu³, Christina J. MacAskill¹, Andrew Dupuis¹, Mark A. Griswold^1,3, Dan Ma^1,3, Chris A. Flask^1,3,4, and Xin Yu^1,3,5

¹Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ²Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States, ³Department of Radiology, Case Western Reserve University, Cleveland, OH, United States, ⁴Department of Pediatrics, Case Western Reserve University, Cleveland, OH, United States, ⁵Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States

Synopsis

Keywords: YIA, Neuro, Neurofluids, Contrast Agents, Acquisition & Reconstruction, MR Fingerprinting, Preclinical

Motivation: Quantitative MRI with sufficient spatiotemporal resolution for mouse brain imaging remains underdeveloped, making whole-brain T₁/T₂ mapping and dynamic contrast agent tracking infeasible.

Goal(s): To develop a 3D MR fingerprinting (MRF) approach for fast, whole-brain T₁ and T₂ mapping, enabling quantitative tracking of contrast agents in the mouse brain.

Approach: We designed a 3D MRF sequence optimized for pre- and post-contrast mouse brain imaging at 9.4T, using GPU-accelerated low-rank reconstruction for robust and efficient data processing.

Results: Our method achieved unprecedented T₁ and T₂ mapping at 192×192×500 μm³, enabling dynamic tracking of contrast agent in cerebrospinal fluid with 4.3-minute temporal resolution.

Impact: This 3D MRF method enables unprecedented quantitative tracking of contrast agents throughout the mouse brain, significantly advancing our ability to study cerebrospinal fluid dynamics and potentially transforming preclinical investigation of neurodegenerative diseases and therapeutic interventions.

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