Abstract #0020

DTI-ALPS-Plus: A New Technique for Measuring Glymphatic System Outflow with Enhanced Sensitivity to ISF and Robustness

Bingjie Jiao¹, Haoting Ge¹, Xue Zhang^2,3, Zejun Wang¹, Biying Lin^4,5, Binbin Sui², Evren Özarslan^6,7, and Ruiliang Bai⁸

¹Key Laboratory of Biomedical Engineering of Education Ministry, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, ²Tiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, ³Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, ⁴School of Medicine，Zhejiang University, Hangzhou, China, ⁵Department of Radiology, Hangzhou First People's Hospital, 261 Huansha Rd, Hangzhou, China, ⁶Department of Biomedical Engineering, Linköping University, Linköping, Sweden, ⁷Centre for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, ⁸Interdisciplinary Institute of Neuroscience and Technology, School of Medicine, Zhejiang University, Hangzhou, China

Synopsis

Keywords: Neurofluids, Diffusion Modeling, Glymphatic System, DTI-ALPS, DTI-ALPS-Plus, Interstitial Fluid

Motivation: The ability of DTI-ALPS to reflect interstitial fluid (ISF) outflow remains controversial.

Goal(s): To demonstrate the ISF’s contribution to DTI-ALPS and propose a method to enhance its sensitivity to ISF dynamics and its robustness.

Approach: The vein orientation was determined from SWI and voxels having medullary veins perpendicular to fiber orientation were semi-automatically selected to calculate DTI-ALPS (i.e., DTI-ALPS-Plus).

Results: DTI-ALPS values decrease as the angle between the orientations of fiber tracts and medullary veins getting further away from 90^o. In comparison with DTI-ALPS, DTI-ALPS-Plus shows significantly larger values, higher inter-observer and scan-rescan repeatability, and better performance in distinguishing AD from healthy controls.

Impact: This work solves the problem of low inter-observer and scan-rescan repeatability in DTI-ALPS by semi-automatically selecting voxels having medullary veins perpendicular to fiber orientation (DTI-ALPS-Plus), which also enhances this method’s sensitivity to ISF dynamics.

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