Keywords: Neurofluids, Neurofluids, T2, perivascular spaces, sulci, ventricles, CSF
Motivation: Earlier studies have measured CSF-T2 values in the sulci and ventricles of healthy subjects; however, these studies lacked sufficient resolution to assess the perivascular spaces (PVS).
Goal(s): We obtained high-resolution multi-echo scans at 7T and compared PVS T2 values with those in the sulci and lateral ventricles.
Approach: We hypothesized that T2 values in the PVS would be lower due to the presence of 'dirty' CSF closer to waste production sites. Six subjects were acquired with multi-echo 7T scans with long echo times, and T2 maps were created.
Results: PVS had shorter T2 values than the sulci and lateral ventricles.
Impact: The reduced T2 values observed in the PVS suggest the presence of 'dirty' CSF, supporting the idea that MR-visible PVS, primarily associated with arteries, may serve not only as channels for fresh CSF inflow but as mixing-sites of waste products.
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