Meeting Banner
Abstract #0021

Perivascular CSF T2 Values compared to Sulcal and Lateral Ventricular CSF: a window into brain clearance pathways

Nina E. Fultz1, Emiel C.A. Roefs1, Martijn Nagtegaal1, Matthias J.P. van Osch1, and Lydiane Hirschler1
1C.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands

Synopsis

Keywords: Neurofluids, Neurofluids, T2, perivascular spaces, sulci, ventricles, CSF

Motivation: Earlier studies have measured CSF-T2 values in the sulci and ventricles of healthy subjects; however, these studies lacked sufficient resolution to assess the perivascular spaces (PVS).

Goal(s): We obtained high-resolution multi-echo scans at 7T and compared PVS T2 values with those in the sulci and lateral ventricles.

Approach: We hypothesized that T2 values in the PVS would be lower due to the presence of 'dirty' CSF closer to waste production sites. Six subjects were acquired with multi-echo 7T scans with long echo times, and T2 maps were created.

Results: PVS had shorter T2 values than the sulci and lateral ventricles.

Impact: The reduced T2 values observed in the PVS suggest the presence of 'dirty' CSF, supporting the idea that MR-visible PVS, primarily associated with arteries, may serve not only as channels for fresh CSF inflow but as mixing-sites of waste products.





How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords