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Abstract #0039

Oral administration of 2H9-choline at human dose for deuterium metabolic imaging of brain tumors

Victor Osoliniec1, Monique A. Thomas1, Robin A. de Graaf1,2, and Henk M. De Feyter1,2
1Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, 2Department of Biomedical Engineering, Yale University, New Haven, CT, United States

Synopsis

Keywords: Deuterium, Metabolism

Motivation: A need for robust metabolic imaging methods to characterize brain tumor lesions.

Goal(s): Explore the potential of oral (PO) deuterated choline at human-recommended doses as a safe alternative to intravenous (IV) infusion, and identify the metabolites contributing to the signal observed in vivo.

Approach: Rat orthotopic glioblastoma models were administered 2H9-choline IV or PO. Deuterium metabolic imaging (DMI) was performed in vivo, and tumor tissue extracts were analyzed using pulse-acquire 2H, and 1H-14N HSQC NMR.

Results: PO 2H9-choline administration provided similar tumor-to-brain image contrast as IV, with the signal originating primarily from phosphocholine and glycerophosphocholine.

Impact: Our results indicate that a lower dose of orally provided deuterated choline generated comparable tumor-to-brain contrast to IV administration, facilitating the potential clinical translation of DMI of deuterated choline.

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