Keywords: Non-Proton, Non-Proton, Neurodegeneration; Biomarkers; Hereditary Spastic Paraplegias; Corticospinal Tract; Diffusion Tensor Imaging; Fractional Anisotropy; Mean Diffusivity; Sodium MRI;
Motivation: Hereditary spastic paraplegia (HSP-SPG4) is characterized by corticospinal tract (CST) degeneration, but current MRI techniques lack sensitivity for early ionic disturbances. There is a need for non-invasive biomarkers to detect these changes and monitor disease progression.
Goal(s): To evaluate sodium MRI as a non-invasive tool for detecting ionic disturbances in the CST of HSP-SPG4 patients.
Approach: 15 patients and 15 controls underwent 3T-MRI with T1-weighted imaging, DTI, and sodium MRI. Sodium concentration and diffusion metrics were analyzed along the CST.
Results: Increased sodium concentrations in the CST correlated with disease duration, suggesting sodium MRI as a potential biomarker for disease monitoring.
Impact: This study demonstrates the potential of sodium MRI as a non-invasive biomarker for early detection of ionic disturbances in HSP-SPG4, enabling improved monitoring of disease progression. It opens avenues for exploring targeted therapies and differentiating HSP-SPG4 from other neurodegenerative disorders.
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