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Abstract #0044

Ionic and Microstructural Alterations in the Corticospinal Tract in SPG4: Insights from Sodium Imaging

Greta Venturi1, Elena Cantoni1, Magali Jane Rochat1, Gianfranco Vornetti1,2, Alessia Quinzi1, Giovanni Rizzo1, Vera Vacchiano 1, Giovanni Sighinolfi1, Fulvio Zaccagna3,4,5, David Neil Manners1,6, Raffaele Lodi1,2, and Caterina Tonon1,2
1IRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy, 2Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy, 3Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 4Department of Imaging, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, 5Investigative Medicine Division, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, 6Department for Life Quality Sciences, University of Bologna, Bologna, Italy

Synopsis

Keywords: Non-Proton, Non-Proton, Neurodegeneration; Biomarkers; Hereditary Spastic Paraplegias; Corticospinal Tract; Diffusion Tensor Imaging; Fractional Anisotropy; Mean Diffusivity; Sodium MRI;

Motivation: Hereditary spastic paraplegia (HSP-SPG4) is characterized by corticospinal tract (CST) degeneration, but current MRI techniques lack sensitivity for early ionic disturbances. There is a need for non-invasive biomarkers to detect these changes and monitor disease progression.

Goal(s): To evaluate sodium MRI as a non-invasive tool for detecting ionic disturbances in the CST of HSP-SPG4 patients.

Approach: 15 patients and 15 controls underwent 3T-MRI with T1-weighted imaging, DTI, and sodium MRI. Sodium concentration and diffusion metrics were analyzed along the CST.

Results: Increased sodium concentrations in the CST correlated with disease duration, suggesting sodium MRI as a potential biomarker for disease monitoring.

Impact: This study demonstrates the potential of sodium MRI as a non-invasive biomarker for early detection of ionic disturbances in HSP-SPG4, enabling improved monitoring of disease progression. It opens avenues for exploring targeted therapies and differentiating HSP-SPG4 from other neurodegenerative disorders.

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Keywords