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Abstract #0045

Sodium signal evolution in kidney imaging at 7T after water intake applying an interleaved sequence scheme for 23Na/1H(pTx) imaging

Judith Schirmer1, Laurent Ruck1, Nico Egger1, Jürgen Herrler2, Sophia Nagelstraßer1, Tobias Wilferth1, Tanja Platt3, Saskia Wildenberg1,4, Andreas K. Bitz4, Christoph Kopp5, Michael Uder1, and Armin M. Nagel1
1Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 2Siemens Healthcare GmbH, Erlangen, Germany, 3Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ) Heidelberg, Heidelberg, Germany, 4FH Aachen – University of Applied Sciences, Aachen, Germany, 5Department of Nephrology and Hypertension, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany

Synopsis

Keywords: Non-Proton, Non-Proton, Sodium MRI, 23Na MRI, High-Field MRI, Interleaved 23Na/1H MRI

Motivation: The sodium medulla-to-cortex ratio (MCR) has previously been shown to be an indicator for kidney function.

Goal(s): Quantification of MCR using an interleaved 23Na/1H(pTx) sequence at 7T.

Approach: Using an interleaved 23Na/1H(pTx) sequence, time-resolved renal 23Na and 1H images were obtained. Segmentation of cortex and medulla was performed on first 1H image after drinking to which all other images were co-registered. After applying B1-/+ corrections for 23Na MRI, the MCR of left and right kidney was calculated for six subjects before and after water intake.

Results: The MCR decreased significantly for both kidneys after water intake, indicating reproducible changes in the MCR.

Impact: This study demonstrates the feasibility of interleaved 23Na/1H(pTx) MRI at 7T to assess renal sodium dynamics non-invasively, allowing exploration of hydration effects on renal sodium balance. Improved B1-correction and respiratory motion correction could enhance early detection of kidney function changes.

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