Abstract #0053

Engineered Biomimetic Iron Oxide Nanoparticles for Early MR Diagnosis and Intervention of Atherosclerotic Vulnerable Plaques

yujie wang¹, qianru zhou², Xiance Zhao³, and Dan Mu⁴

¹Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Jiangsu University, No. 321 Zhongshan Road, Nanjing, 210008, China., Nanjing, China, ²Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, No. 321 Zhongshan Road, Nanjing, 210008, China., Nanjing, China, ³Philips Healthcare, Shanghai, China, Nanjing, China, ⁴Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, No. 321 Zhongshan Road, Nanjing, 210008, China., Nanjing, China

Synopsis

Keywords: Atherosclerosis, Atherosclerosis

Motivation: The identification and intervention of atherosclerotic plaques is effective to prevent cardiovascular events. However, specific detection methods in vivo are lacking.

Goal(s): The objective of this study was to prepare M2-PNVs@Fe3O4 and to improve the accuracy of contrast agent delivery.

Approach: In vitro, the contrast agent was co-cultured with Raw264.7, HUVEC and collagen, respectively. In vivo, the fluorescence imaging and MRI contrast-enhancing effect was investigated in mice.

Results: The contrast agent has good targeting of vulnerable plaques, and high SNR were obtained on T2WI sequences. In addition, the contrast agent effectively attenuates the levels of inflammatory factors.

Impact: We prepared biomimetic contrast agent to improve the targeting specificity of vulnerable plaques, which is a major innovation in the application of bionic nanotechnology to atherosclerosis. Meanwhile, this study provided ideas for the integration diagnosis and treatment of contrast agents.

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