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Abstract #0061

Free-breathing High-resolution 3D Whole-heart Adiabatic T1ρ Mapping at 0.55T

Dongyue Si1, Michael G Crabb1, Simon J Littlewood1, Karl P Kunze1,2, Claudia Prieto1,3, and René M Botnar1,3,4,5,6
1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2MR Research Collaborations, Siemens Healthcare Limited, Camberley, United Kingdom, 3School of Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, 4Millennium Institute for Intelligent Healthcare Engineering, Santiago, Chile, 5Institute of Biological and Medical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, 6Institute for Advanced Study, Technical University of Munich, Garching, Germany

Synopsis

Keywords: Myocardium, Low-Field MRI, Parametric mapping

Motivation: Cardiac T1ρ mapping is promising for non-contrast myocardial scar assessment. However, there is scarce experience with T1ρ mapping at low-field. In a recent study, T1ρ produced by continuous wave spin-lock (SL) pulses demonstrated limited T1ρ dispersion at low-field.

Goal(s): To devise an efficient 3D free-breathing high-resolution T1ρ mapping sequence based on adiabatic SL pulses at 0.55T with improved dispersion.

Approach: The proposed sequence acquires four motion-corrected 3D volumes using saturation and adiabatic SL preparation pulses for T1ρ mapping.

Results: The proposed 3D T1ρ sequence shows excellent agreement with reference sequence in phantom and provides comparable T1ρ results with a 2D sequence in-vivo.

Impact: The proposed 3D T1ρ mapping sequence demonstrates the feasibility of non-invasive myocardial tissue characterization at 0.55T with 2mm isotropic-resolution in an efficient free-breathing scan of 7 mins. Both phantom and in-vivo 3D T1ρ measurements showed excellent agreements with reference sequences.

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