Abstract #0075
7T MRSI ratios can predict the presence of 5-ALA fluorescence in gliomas comparable to T1w-CE and PET
Sara Huskic1,2, Philipp Lazen1,2, Cornelius Cadrien1,2, Nicolas Weilguny1, Thomas Roetzer-Pejrimovsky3, Julia Furtner4,5, Johannes Leitner4, Anita Kloss-Brandstaetter6, Matthias Preusser7, Tatjana Traub-Weidinger8, Karl Roessler1,9, Siegfried Trattnig2,9, Günther Grabner10, Wolfgang Bogner2,9, Georg Widhalm1, and Gilbert Hangel1,2,9,11
1Department of Neurosurgery, Medical University of Vienna, Vienna, Austria, 2High-field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 3Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, Vienna, Austria, 4Division of Neuroradiology and Musculoskeletal Radiology, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 5Research Center of Medical Image Analysis and Artificial Intelligence (MIAAI), Danube Private University, Krems, Austria, 6Department of Engineering & IT, Carinthia University of Applied Sciences, Villach, Austria, 7Division of Oncology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria, 8Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 9Christian Doppler Laboratory for MR Imaging Biomarkers, Vienna, Austria, 10Department of Medical Engineering, Carinthia University of Applied Sciences, Klagenfurt, Austria, 11Functional Imaging Laboratory, Department of Imaging Neuroscience, UCL Queen Square Institute of Neurology, University College London, Vienna, Austria
Synopsis
Keywords: Tumors (Pre-Treatment), Spectroscopy, Glioma, 5-ALA Fluorescence
Motivation: The role of MRSI in predicting 5-ALA fluorescence in gliomas has not yet been explored.
Goal(s): Our goal was to test if 7T MRSI is able to predict the presence of 5-ALA fluorescence and to compare it to CE MRI and PET.
Approach: We retrospectively evaluated 5-ALA fluorescence, 7T MRSI ratio levels, PET TNRs and T1w-CE in 30 glioma patients. Further, we tested their abilities to predict 5-ALA fluorescence using ROC curves.
Results: ROC curves indicate that Gln/tCr, Gly/tCr, Ser/tCr and GSH/tCr have the potential to predict 5-ALA fluorescence, with performance comparable to CE and PET.
Impact: Our results show that 7T MRSI is a powerful tool for predicting 5-ALA fluorescence in gliomas and can be useful in therapy planning. It would be valuable to investigate the spatial correlation between 7T MRSI and areas of 5-ALA fluorescence.
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