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Abstract #0076

Similarity of biological information captured by 68Ga-PSMA-11 PET and arterial spin labeling perfusion imaging in glioblastoma

Yuping Han1, Wanjun Hu1, Yongjun Luo2, Xiangrong Cao3, Yamin Sun4, and Jing Zhang1
1Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China, 2Department of Nuclear Medicine, Lanzhou University Second Hospital, Lanzhou, China, 3Department of Radiotherapy, Lanzhou University Second Hospital, Lanzhou, China, 4Department of Pathology, Lanzhou University Second Hospital, Lanzhou, China

Synopsis

Keywords: Tumors (Pre-Treatment), Arterial spin labelling, Positron emission tomography, prostate-specific membrane antigen

Motivation: Targeting glioblastoma microvasculature using prostate-specific membrane antigen (PSMA) ligands for diagnosis and treatment represents a promising area of recent research.

Goal(s): This study aimed to investigate the relationship between PSMA PET and arterial spin labeling (ASL) perfusion imaging, and their correlation with immunohistochemical microvascular indices.

Approach: We investigated correlation between derived parameters of ASL and PSMA PET. Microvascular indices PSMA and microvascular density (MVD) was assessed and its correlation with imaging was analysed.

Results: Our results highlight the similarity of biological information captured by PSMA PET and ASL in GBM, tracer uptake on PSMA PET can reliably reflect MVD and perfusion of tumors.

Impact: These findings may be valuable for further revealing the potential mechanisms underlying PSMA tracer uptake, and also provide support for PSMA-targeted radiotherapy as a viable treatment option for patients with glioblastoma.

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Keywords