Keywords: Tumors (Pre-Treatment), Arterial spin labelling, Positron emission tomography, prostate-specific membrane antigen
Motivation: Targeting glioblastoma microvasculature using prostate-specific membrane antigen (PSMA) ligands for diagnosis and treatment represents a promising area of recent research.
Goal(s): This study aimed to investigate the relationship between PSMA PET and arterial spin labeling (ASL) perfusion imaging, and their correlation with immunohistochemical microvascular indices.
Approach: We investigated correlation between derived parameters of ASL and PSMA PET. Microvascular indices PSMA and microvascular density (MVD) was assessed and its correlation with imaging was analysed.
Results: Our results highlight the similarity of biological information captured by PSMA PET and ASL in GBM, tracer uptake on PSMA PET can reliably reflect MVD and perfusion of tumors.
Impact: These findings may be valuable for further revealing the potential mechanisms underlying PSMA tracer uptake, and also provide support for PSMA-targeted radiotherapy as a viable treatment option for patients with glioblastoma.
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