Keywords: Tumors (Pre-Treatment), IVIM, Glioma, Habitat imaging
Motivation: Intratumor heterogeneity (ITH) is closely correlated with the poor prognosis of high-grade glioma (HGG). There remains a need for developing preoperative noninvasive biomarkers to assess the ITH and prognosis. Habitat imaging has shown promising potential in this regard.
Goal(s): To utilize habitat analysis based on intravoxel incoherent motion (IVIM)-MRI to explore imaging markers that predict overall survival (OS) for HGG patients.
Approach: Clustering voxels from IVIM-MRI parametric maps to generate spatial subregions, followed by analyzing the relationship between quantitative image features and patient survival.
Results: Habitat analysis derived from IVIM-MRI is an effective tool for predicting the prognosis of HGG patients.
Impact: Preoperative perfusion and diffusion heterogeneity identified by habitat analysis from IVIM-MRI were associated with the OS of HGG patients. The specific tumor subregion with prognostic value may help to refine the understanding of glioma ITH and contribute to future treatments.
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