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Abstract #0078

Exchange time from time-dependent diffusion-weighted MRI as a potential biomarker for treatment response in human brain metastasis.

Elise Gwyther1, James Powell2, Sahar Iqbal2, Jennifer Golten2, Beat Jucker3, Maëliss Jallais1, Derek Jones1, Chantal M.W. Tax1,4, and Marco Palombo1,5
1CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom, 2Velindre Cancer Centre, Cardiff, United Kingdom, 3Precision Medicine, Development, GlaxoSmithKline, Royersford, PA, United States, 4University Medical Center Utrecht, Utrecht, Netherlands, 5School of Computer Science and Informatics, Cardiff University, Cardiff, United Kingdom

Synopsis

Keywords: Tumors (Post-Treatment), Tumors

Motivation: Previous studies linking exchange time τex in brain metastases to treatment response have been dependent on the usage of Gadolinium contrasts agents for DCE-MRI.

Goal(s): Determine whether τex estimated using diffusion time dependent kurtosis from diffusion-weighted MRI before and after stereotactic radiosurgery (SRS) is correlated with treatment response for brain metastases.

Approach: Estimating changes in τex from time dependent kurtosis in a pilot cohort of 16 patients with brain metastases from multiple primary cancers before and after SRS and correlate them with treatment response using RANO-BM criteria.

Results: All patients in the good/poor response groups (RANO-BM=1-2/3-4) had negative/positive changes in τex, respectively.

Impact: We provide evidence that estimates of exchange time in brain metastases using diffusion time dependent kurtosis is a potential biomarker to characterize treatment response using endogenous water contrast.

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