Keywords: Tumors (Post-Treatment), Tumors
Motivation: Previous studies linking exchange time τex in brain metastases to treatment response have been dependent on the usage of Gadolinium contrasts agents for DCE-MRI.
Goal(s): Determine whether τex estimated using diffusion time dependent kurtosis from diffusion-weighted MRI before and after stereotactic radiosurgery (SRS) is correlated with treatment response for brain metastases.
Approach: Estimating changes in τex from time dependent kurtosis in a pilot cohort of 16 patients with brain metastases from multiple primary cancers before and after SRS and correlate them with treatment response using RANO-BM criteria.
Results: All patients in the good/poor response groups (RANO-BM=1-2/3-4) had negative/positive changes in τex, respectively.
Impact: We provide evidence that estimates of exchange time in brain metastases using diffusion time dependent kurtosis is a potential biomarker to characterize treatment response using endogenous water contrast.
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