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Abstract #0128

Combination of MR Cell Size Imaging and Magnetization Transfer Imaging to Predict Intestinal Disease Progression in Crohn’s Disease

Xinyue Wang1, Li Huang1, Ren Mao1, Zhong-wei Zhang2, Xiaodi Shen1, Qingzhu Zheng1, Ruonan Zhang1, Yangdi Wang1, Luyao Wu1, Yaoqi Ke1, Chen Zhao3, Mengzhu Wang4, Zhoulei li1, Zhenpeng Peng1, Can hui Sun1, Shi-ting Feng5, and Xuehua Li5
1The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China, 2Washington University School of Medicine, Saint Louis, MO, United States, 3MR Research Collaboration, Siemens Healthineers, Guangzhou, China, 4MR Research Collaboration, Siemens Healthineers, Beijing, China, 5The First Affiliated Hospital, Sun Yat-Sen University, GuangZhou, China

Synopsis

Keywords: Microstructure, Microstructure, Crohn’s disease

Motivation: Intestinal fibrosis assessment by simultaneously characterizing mesenchymal cells and extracellular collagen may help predict disease progression in patients with Crohn’s disease (CD).

Goal(s): To evaluate the efficacy of time-dependent diffusion MRI (TD-dMRI) in characterizing cellular properties, and combine it with magnetization transfer (MT)-MRI to depict intestinal fibrosis and predict disease progression.

Approach: 124 CD patients (31 received surgery) were prospectively enrolled and underwent TD-dMRI to map fibrotic microstructures and MT-MRI to quantify collagen levels. 93 nonsurgical patients were followed up.

Results: TD-dMRI-derived cell diameter (d) was highly correlated with myofibroblasts/fibroblasts-area-ratio (r=0.58; P<0.001). d was significant risk factor for disease progression (HR: 1.2; P=0.001).

Impact: TD-dMRI-derived d effectively characterizes fibrosis-associated cellular microstructures in patients with CD, and combined with normalized MT ratio enables a comprehensive assessment of intestinal fibrosis and thus accurate prediction of disease progression.

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