Abstract #0136

First observation in a human of real-time BOLD-fMRI response to epileptic seizure

Giovanni Sighinolfi¹, Gianfranco Vornetti^1,2, Elena Pasini¹, Elena Cantoni¹, Lorenzo Ferri¹, David Neil Manners^1,3, Matteo Martinoni¹, Roberto Michelucci¹, Raffaele Lodi^1,2, and Caterina Tonon^1,2

¹IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy, ²Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy, ³Department for Life Quality Studies, University of Bologna, Bologna, Italy

Synopsis

Keywords: Epilepsy, Epilepsy, resting-state fMRI, BOLD signal

Motivation: While the potential of fMRI to localize the seizure onset zone (SOZ) and epileptic networks has been widely described, BOLD response to an epileptic seizure has not been previously reported.

Goal(s): To provide the first description of the real-time BOLD response to an epileptic seizure and characterize its evolution with respect to the timeseries of the SOZ.

Approach: We applied independent component analysis and cross-correlation on resting-state fMRI data acquired during a seizure in a patient with temporal epilepsy.

Results: The SOZ BOLD peaked after ~19s from seizure onset. A simultaneous propagation network was identified. Other brain networks had anti-correlated and delayed evolution.

Impact: This is the first description of real-time BOLD response to an in-scanner epileptic seizure in a human and improves our knowledge on the mechanisms of brain function following such events.

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