Abstract #0161

Non-contrast Imaging of Knee Synovitis in Rheumatoid Arthritis: Comparison of T1 and T2 Mapping with Dynamic Contrast-Enhanced MRI

Stefan Zbyn^1,2,3, Richard Lartey^1,2, Brendan Eck^1,2,3, Ceylan Colak³, M. Elaine Husni⁴, Xiaojuan Li^1,2,3, and Carl S. Winalski^1,2,3

¹Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, United States, ²Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States, ³Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, ⁴Department of Rheumatic and Immunologic Diseases, Medical Specialty Institute, Cleveland Clinic, Cleveland, OH, United States

Synopsis

Keywords: Osteoarthritis, Inflammation

Motivation: Dynamic contrast-enhanced (DCE)-MRI can quantify synovial inflammation (synovitis) in rheumatoid arthritis (RA) but requires intravenous contrast administration. Non-contrast T1 mapping has recently been proposed as an alternative for synovitis evaluation.

Goal(s): This study aims to quantify T1 and T2 values in the synovium of RA patients with synovitis and correlate them with DCE-MRI parameters.

Approach: Eight RA patients underwent 3T MRI to quantify T1, T2, and DCE-MRI parameters in synovium regions segmented on T1- and proton-density-weighted images.

Results: Synovium T1 values correlated positively with DCE-MRI parameters highlighting the potential of T1 mapping as a non-contrast alternative to DCE-MRI for assessing knee synovitis.

Impact: This study highlights the potential of T1 mapping as an alternative to contrast-enhanced MRI for assessing knee synovitis in patients with rheumatoid arthritis. T1 mapping may facilitate broader evaluation of knee synovitis, especially in patients with contraindications to contrast-enhanced MRI.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.