Abstract #0168

Spatiotemporal changes in the uterus during non-labor contractions

Esra Abaci Turk^1,2, Neel Dey³, Elfar Adalsteinsson^4,5,6, Polina Golland⁴, and P. Ellen Grant^1,2

¹Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children's Hospital, Boston, MA, United States, ²Harvard Medical School, Boston, MA, United States, ³Computer Science and Artificial Intelligence Laboratory (CSAIL), Massachusetts Institute of Technology, Cambridge, MA, United States, ⁴Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁵Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁶Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States

Synopsis

Keywords: Placenta, Placenta

Motivation: Uteroplacental perfusion can be temporarily compromised by non-labor uterine contractions.

Goal(s): We performed a quantitative, image-based analysis of the spatiotemporal uterine, myometrium, and placental changes associated with non-labor contractions.

Approach: The temporal volumetric changes in the uterus and myometrium, and their correlation with changes in placental volume and T2*, were determined. We also compared volume and T2* changes in placental cotyledons to the surrounding interstitial spaces.

Results: Consistent volume decreases in the uterus and myometrium were observed together with decreases in placental volume and T2*. Significantly more deformation and faster decreases in T2* were observed in placental cotyledons compared to the interstitial spaces.

Impact: Non-labor contractions consistently correlate with placental volume and T2* decreases with faster changes in cotyledons. Contractions likely eject maternal blood out of the placenta resulting in transient hypoxic stress. Imaging contractions may provide insight into hypoxic stress for the fetus.

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