Abstract #0246

Anesthetics Modulate Cerebrospinal Fluid Efflux Pathways in Mice by Changing the Perineural and Perivascular Spaces

Haoting Ge¹, Xiaoyan Gu², Shuyuan Tan¹, Bingjie Jiao¹, Qingping He³, Lili Zhang⁴, and Ruiliang Bai⁵

¹Key Laboratory of Biomedical Engineering of Education Ministry, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, ²Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China, ³School of Medicine, Zhejiang University, Zhejiang China, Hangzhou, China, ⁴Institute of Brain and Cognitive Science of Zhejiang, Hangzhou City University, Hangzhou, China, Hangzhou, China, ⁵Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University School of Medicine, Hangzhou, China

Synopsis

Keywords: Neurofluids, Neurofluids, Cerebrospinal fluid efflux pathway, Anesthetics, Cerebrospinal fluid volume

Motivation: Anesthesia could affect neurofluid circulation, but its impact on cerebrospinal fluid (CSF) drainage remains unclear.

Goal(s): We aimed to clarify the detailed CSF efflux pathways from the brain to the periphery under different anesthetics.

Approach: We performed dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and structure MRIs in mice under three anesthesia protocols (isoflurane alone (ISO), isoflurane plus dexmedetomidine (DEXI), and ketamine/xylazine (K/X)).

Results: ISO significantly accelerates CSF outflow via the nasopharyngeal lymphatic plexus but slows it through the paraspinal space compared to DEXI and K/X. For the jugular ganglion, K/X significantly retards CSF outflow relative to DEXI and ISO.

Impact: Different anesthesia protocols could affect the CSF outflow pathways, and the CSF volume changes under different anesthesia protocols are the potential mechanism.

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