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Abstract #0252

3-Tesla Parasagittal dural space (PSD) T2 relates to PSD volume and correlates with diurnal circadian oscillation during wakefulness

Kilian Hett1, Melanie Leguizamon1, Colin D. McKnight2, Alexander Song1, Caleb Han1, Abigail Dubois1, Maeve Curtin1, Maria Garza1, Paula Trujillo1, Ciaran M. Considine1, Daniel O. Claassen1, and Manus J. Donahue1,3
1Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, 2Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 3Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, United States

Synopsis

Keywords: Neurofluids, Neurofluids, Parasagittal dural space, CSF

Motivation: The parasagittal dural space (PSD) has been shown to harbor meningeal lymphatic vessels and is hypothesized to play a fundamental role in CSF egress and neuroimmune functions. While PSD hypertrophy has been demonstrated with age and neurodegeneration, limited information is available on the composition of this space.

Goal(s): To provide quantitative measures of PSD T2 and investigate potential relationships between T2 and diurnal variation, which is known to alter neurofluid circulation kinetics.

Approach: A long-TE, multi-echo T2-weighted turbo-spin-echo sequence was repeated four times over day in 15 healthy adults.

Results: PSD T2 was 240.6±57.2 ms and increased from morning to evening.

Impact: The T2 relaxation times of water in the parasagittal dural (PSD) space were quantified over the circadian cycle of wakefulness at using a long-TE multi-echo turbo-spin-echo sequence. PSD T2 was 240.6±57.2 ms on average and increased from morning to evening.

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