Keywords: Neurofluids, Neurofluids, Glymphatic hypothesis, SLYM
Motivation: Understanding water dynamics on the cerebral surface is crucial for advancing neurofluid research and exploring the glymphatic hypothesis and the subarachnoid lymphatic-like membrane (SLYM).
Goal(s): Detailed visualization of water dynamics on the surface of the brain using a water tracer.
Approach: 17O-labeled water was directly injected into the subarachnoid space (SAS) of the rat cerebrum to increase local concentration for detailed observation of water dynamics.
Results: The inner SAS group showed a higher concentration of 17O-labeled water, with vertical distribution patterns observed on the cortical surface, suggesting potential pathways for CSF flow into brain parenchyma.
Impact: Using the technique of local subarachnoid injection of 17O-labeled water and an optimiszd proton MRI method, we were the first to visualize CSF inflow pathways in the cerebral cortex as distinct signal changes.
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