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Abstract #0271

In-vivo quantitative histology using 0.36-mm MR Fingerprinting: technical development

Xiaozhi Cao1,2, Alexander Beckett3,4, Congyu Liao1,2, Mengze Gao1, Erica Walker3, Zheren Zhu5, Adam Kerr2, Yang Yang5, David Feinberg3,4, and Kawin Setsompop1,2
1Department of Radiology, Stanford University, Stanford, CA, United States, 2Department of Electrical Engineering, Stanford University, Stanford, CA, United States, 3Helen Wills Neuroscience Institute, University of California, Berkeley, CA, United States, 4Advanced MRI Technologies, Sebastopol, CA, United States, 5Department of Radiology, University of California, San Francisco, CA, United States

Synopsis

Keywords: High-Field MRI, High-Field MRI

Motivation: Motivated by the need for high-resolution and accurate MRI imaging in in-vivo histology, this study aims to advance quantitative MRI acquisition to 360-mm isotropic resolution.

Goal(s): To achieve precise, robust, and high-quality 0.36-mm MR fingerprinting technique for in-vivo whole-brain quantitative imaging.

Approach: The study integrates high-temporal motion correction, rapid and high-quality field inhomogeneity estimation, deep-learning-based spatially-varying denoising, and system correction into a 3D MRF framework, implemented on a high-performance 7T NexGen scanner.

Results: This work enables in-vivo T1 and T2 maps with unprecedented 0.36-mm isotropic resolution and the results show successful imaging of fine structures like small nucleus and stria of Gennari.

Impact: This work provides a high-quality, motion-robust, and field-inhomogeneity-robust quantitative tool, enabling whole-brain T1 and T2 maps at 0.36-mm resolution, unprecedented for in-vivo quantitative imaging. It makes in-vivo quantitative histology research feasible, providing possibility to quantitative analysis on fine brain structures.

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Keywords