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Abstract #0272

Simultaneous T1 and T2 mapping of the brain at 7 Tesla with optimized and accelerated QuantoRAGE

Gabriele Bonanno1,2,3, Tâm Johan Nguyên1,2,3, José P Marques4, Thomas Yu5,6,7, Dominik Nickel8, Berk Can Açikgöz3,9,10, Jessica AM Bastiaansen3,9, Roland Kreis2,3, Piotr Radojewski3,11, Bénédicte Maréchal5,6,7, Tobias Kober5,6,7, and Tom Hilbert5,6,7
1Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Bern, Switzerland, 2Magnetic Resonance Methodology, Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Bern, Switzerland, 3Translational Imaging Center, Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland, 4Donders Institute for Brain Cognition and Behaviour, Radboud University, Nijmegen, Netherlands, 5Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland, 6Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 7LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 8Siemens Healthineers AG, Forchheim, Germany, 9Department of Diagnostic, Interventional and Pediatric Radiology (DIPR), University Hospital Bern, Bern, Switzerland, 10Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland, 11Support Center for Advanced Neuroimaging, Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Bern, Switzerland

Synopsis

Keywords: High-Field MRI, Quantitative Imaging, Brain, UHF

Motivation: T1 and T2 relaxometry may provide valuable information for early detection and characterization of pathology at UHF but requires long scan times for large coverage and high-resolution.

Goal(s): To enable fast simultaneous T1 and T2 mapping at 7T for the whole brain.

Approach: The accelerated QuantoRAGE sequence used two scans with various T2 preparations and inversion times that were optimized using Cramér-Rao lower bound. A dictionary fitting model was then employed for T1 and T2 quantification.

Results: QuantoRAGE showed feasibility for high-resolution T1 and T2 mapping in <7 minutes and provided values in good agreement with reference methods in phantom and healthy brains.

Impact: QuantoRAGE allows for simultaneous T1 and T2 mapping of the whole brain at ultra-high field with high isotropic resolution and in less than 7 minutes, bringing quantitative MRI closer to clinical UHF applications.

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Abstract Presentation Video

Keywords