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Abstract #0273

Quantify blood transit time in cerebral arteries using 4D-MRA with example clinical application in moyamoya disease

Alex A Bhogal1, Simone M. Uniken Venema2, Pieter T Deckers2, Kim van de Ven3, Maarten Versluis3, Kees P Braun4, Albert A van der Zwan4, and Jeroen C.W. Siero5
1Department of Radiology, Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands, 2Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, Netherlands, 3Philips, Best, Netherlands, 4Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, Netherlands, 5University Medical Center Utrecht, Utrecht, Netherlands

Synopsis

Keywords: Stroke, Blood vessels, MRA

Motivation: Angiography is critical for visualizing cerebral blood flow in intracranial steno-occlusive diseases. Current 4D magnetic resonance angiography (MRA) techniques primarily focus on macrovascular structures, yet few have quantified hemodynamic timing.

Goal(s): This study introduces a novel model to estimate macrovascular arterial transit time (mATT) derived from arterial spin labeling (ASL)-based 4D-MRA.

Approach: Our method allows to visualize mATT differences throughout the brain in patients with intracranial steno-occlusive disease, as well as changes in mATT resulting from the cerebrovascular reactivity response to an acetazolamide (ACZ) injection.

Results: We quantify signal dynamics from 4D-MRA enabling comparison with complementary 3D hemodynamic parameter maps or structural information.

Impact: This approach offers a non-invasive, quantitative assessment of macrovascular dynamics, with potential to enhance understanding of large-vessel and tissue-level hemodynamics and augment monitoring of treatment outcomes in steno-occlusive disease patients.

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