Keywords: Stroke, Blood vessels, MRA
Motivation: Angiography is critical for visualizing cerebral blood flow in intracranial steno-occlusive diseases. Current 4D magnetic resonance angiography (MRA) techniques primarily focus on macrovascular structures, yet few have quantified hemodynamic timing.
Goal(s): This study introduces a novel model to estimate macrovascular arterial transit time (mATT) derived from arterial spin labeling (ASL)-based 4D-MRA.
Approach: Our method allows to visualize mATT differences throughout the brain in patients with intracranial steno-occlusive disease, as well as changes in mATT resulting from the cerebrovascular reactivity response to an acetazolamide (ACZ) injection.
Results: We quantify signal dynamics from 4D-MRA enabling comparison with complementary 3D hemodynamic parameter maps or structural information.
Impact: This approach offers a non-invasive, quantitative assessment of macrovascular dynamics, with potential to enhance understanding of large-vessel and tissue-level hemodynamics and augment monitoring of treatment outcomes in steno-occlusive disease patients.
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