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Abstract #0278

Respiration Can Trigger Cerebrovascular Reactivity: A New Method to Quantify Respiratory-Driven CVR Using Real-time phase contrast MRI

Pan LIU1,2, QiuTing Wen3, Kimi Owashi1,2, and Olivier Balédent1,2
1CHU Amiens-Picardie, University Hospital, Amiens, France, 2CHIMERE EA.7516, Amiens, France, 3Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States

Synopsis

Keywords: Blood Vessels, Velocity & Flow, Cerebrovascular Reactivity, CVR, phase contrast, real-time phase contrast, neurofluids

Motivation: Quantifying cerebrovascular reactivity (CVR) is key for diagnosing and understanding neurological diseases. However, measuring respiratory-driven CVR is challenging due to the difficulty in separating cardiac effects from CVR modulation.

Goal(s): Propose a novel approach to accurately quantify respiratory-driven CVR.

Approach: Using real-time phase-contrast sequences and respiratory signals to quantify respiratory-driven CVR by analysing the flow ratio (Ratio-Q) between the internal and external carotid arteries.

Results: Sustained deep breathing increases cerebrovascular resistance causing a 20% reduction in average carotid artery flow and Ratio-Q. CVR also regulates cerebrovascular resistance at the respiratory frequency, stabilizing cerebral blood flow fluctuations.

Impact: This study introduces a new, effective method for measuring respiratory-driven CVR, comparing results across two different breathing modes. It provides crucial methodological support and reference data for clinical and physiological research.

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Keywords