Keywords: Stroke, Stroke, oxygen extraction fraction, OEF, quantitative susceptibility mapping, quantitative blood oxygen level dependent imaging, QSM, qBOLD, QSM+qBOLD, QQ
Motivation: Predicting disease progression and clinical outcomes in stroke remains challenging. Oxygen extraction fraction (OEF), which assesses tissue viability, is a promising biomarker for predicting disease progression.
Goal(s): To determine if OEF can predict long-term recovery outcomes in ischemic stroke patients and if OEF evolution differs between patients with good and poor recovery.
Approach: We analyzed OEF at 1 days, 10 days, 1 months, and 3 months in 25 stroke patients.
Results: OEF trajectories differed between good (mRS≤2) and poor (mRS>2) recovery groups. Clinical outcomes (mRS score at 3 months) were positively associated with initial OEF and negatively with initial OEF change.
Impact: This study demonstrated the feasibility of QQ-based OEF mapping as a predictive tool for ischemic stroke recovery, enabling clinicians to integrate early OEF measurements into treatment decisions, potentially improving patient outcomes.
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