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Abstract #0279

Dynamic Changes in Oxygen Extraction Fraction as a Predictor of Long-Term Recovery in Ischemic Stroke Patients

Quinn Boyer1, Di Wu2, Shun Zhang2, and Junghun Cho1
1Department of Biomedical Engineering, University at Buffalo, Buffalo, NY, United States, 2Department of Radiology, Tongji Medical College, Wuhan, China

Synopsis

Keywords: Stroke, Stroke, oxygen extraction fraction, OEF, quantitative susceptibility mapping, quantitative blood oxygen level dependent imaging, QSM, qBOLD, QSM+qBOLD, QQ

Motivation: Predicting disease progression and clinical outcomes in stroke remains challenging. Oxygen extraction fraction (OEF), which assesses tissue viability, is a promising biomarker for predicting disease progression.

Goal(s): To determine if OEF can predict long-term recovery outcomes in ischemic stroke patients and if OEF evolution differs between patients with good and poor recovery.

Approach: We analyzed OEF at 1 days, 10 days, 1 months, and 3 months in 25 stroke patients.

Results: OEF trajectories differed between good (mRS≤2) and poor (mRS>2) recovery groups. Clinical outcomes (mRS score at 3 months) were positively associated with initial OEF and negatively with initial OEF change.

Impact: This study demonstrated the feasibility of QQ-based OEF mapping as a predictive tool for ischemic stroke recovery, enabling clinicians to integrate early OEF measurements into treatment decisions, potentially improving patient outcomes.

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Keywords