Meeting Banner
Abstract #0290

Are we ready for 23Na MRI-based functional mapping with a 14 Tesla scanner?

Xin Yu1, Yuanyuan Jiang1, Grace Yu1, Xiaochen Liu1, and Xiaoqing Alice Zhou1
1Massachusetts General Hospital, Charlestown, MA, United States

Synopsis

Keywords: fMRI Acquisition, Acquisition Methods, 23Na, fMRI, neuronal activity, ultra-fast, high field, x-nuclei

Motivation: We need to develop novel methods to map brain function that go beyond traditional hemodynamic-based fMRI techniques

Goal(s): To map the local field potential in the scale of tens of millisecond with 23Na-based fMRI, as well as sodium-based cerebral blood volume fMRI.

Approach: We use reshuffled k-t space FLASH method for 23Na-MRI with 10 ms/frame sampling rate. Implantable RF coils with dual oscillating mode enable high SNR for 23Na-response(NaR)-MRI and SOdium-Based(SOBA)-fMRI.

Results: We detected ultra-fast negative NaR signals near activated somatonsesory cortex and positive SOBA fMRI signals as surrogate control of the SNR.

Impact: We investigate the feasibility of 14T rodent 23Na MRI for brain functional mapping with 10ms/frame sampling rate and a voxel size of 0.24-0.35µl.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords