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Abstract #0293

Median-anchored Generalized Linear Binning vs Conventional Methods to Quantify 129Xe Lung Ventilation MRI

Riaz Hussain1, Joseph W Plummer2,3, Abdullah S Bdaiwi1, Matthew M Willmering1,4, Laura L Walkup2,3,4,5, and Zackari I Cleveland2,3,4,5
1Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2Division of Pulmonary Medicine1. Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 3Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, United States, 4Department of Pediatrics, University of Cincinnati, Cincinnati, OH, United States, 5Imaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States

Synopsis

Keywords: Hyperpolarized MR (Gas), Hyperpolarized MR (Gas)

Motivation: Hyperpolarized (HP) 129Xe MRI is an accepted method to assess lung ventilation, but there is no robust, standardized method to quantify impaired ventilation, and existing analysis methods have not been compared comprehensively.

Goal(s): To define impaired ventilation via HP-129Xe ventilation defect percentage (VDP) using median-anchored generalized linear binning (Median) and benchmark performance against established methods.

Approach: HP-129Xe VDP was calculated from 10 healthy controls and 18 people with cystic fibrosis using the proposed and 5 established methods, including reader defect-scoring.

Results: Median-anchoring improved robustness and agreed better with reader-scoring, indicating the potential to consistently and reliably quantify VDP.

Impact: Median-anchored generalized linear binning analysis of HP-129Xe ventilation images enabled improved detection of subtle ventilation impairments in people with cystic fibrosis. This method shows promise for broader applications across obstructive diseases, advancing early diagnosis and disease monitoring.

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Keywords