Meeting Banner
Abstract #0296

Evaluating the acute response to oxygen using hyperpolarized 129-xenon dissolved-phase MRSI interleaved with global MRS in a porcine model

Michael Vaeggemose1,2, Markus P. Andersen3, Mattias H. Kristensen3, Esben S. S. Hansen3, Christoffer Laustsen3, and Rolf F. Schulte4
1Aarhus University, Aarhus, Denmark, 2GE HealthCare, Brøndby, Denmark, 3Aarhus University, Aarhus N, Denmark, 4GE HealtCare, Munich, Germany

Synopsis

Keywords: Hyperpolarized MR (Gas), Hyperpolarized MR (Gas)

Motivation: Hyperpolarized xenon (129Xe) gas reveals key characteristics of pulmonary physiology such as ventilation and alveolar-capillary gas transfer. Dissolved-phase red blood cell (RBC) oscillations have been shown to improve detection of pulmonary arterial hypertension.

Goal(s): Implement and validate dissolved-phase MRSI with interleaved MRS to image gas transfer and RBC oscillations.

Approach: MRSI and interleaved MRS were acquired in 15 s breath-hold with an image resolution of 2x2x3 cm. RBC oscillations were evaluated in 14 healthy pigs under vasoactive interventions of 15% (capillary constriction), 21% (atmosphere) and 40% (capillary dilation) oxygen concentration.

Results: RBC oscillations increased in amplitude with oxygen concentration.

Impact: The study implements and validates a dissolved-phase MRSI with interleaved MRS to image gas transfer and RBC oscillations during vasoactive interventions. Alveolar-capillary modulation effects on blood oscillations are crucial for the methods application in detection of pulmonary arterial hypertension detection.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords