Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas)
Motivation: RNA virus infections, including COVID-19 and influenza, often cause long-lasting symptoms such as sensory loss, depression, and anxiety, with no objective evaluation methods currently available.
Goal(s): This study aims to detect brain dysfunction by monitoring metabolic changes using hyperpolarized 13C MRI.
Approach: A polyI:C-induced pseud-infection/immunological fatigue model mice was used. On days 3, 14, and 28 post-administration, chemical shift imaging of parahydrogen-polarized [1-13C] pyruvate metabolism, behavioral tests, and analyses of metabolic markers and neurotransmitters were conducted.
Results: The pseud-infection model showed sustained glycolytic shifts, with significant correlations between LDH-A and TPH2 expressions, and between phosphorylated PDH and serotonin levels.
Impact: Brain metabolic alterations measured by hyperpolarized 13C pyruvate MRI may reflect neurological dysfunction associated with serotonin abnormalities, suggesting its potential as a diagnostic tool for identifying brain impairments linked to RNA virus infections and related neuropsychiatric conditions.
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