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Abstract #0302

Imaging Brain Perfusion Using Time-encoded PCASL and Hyperpolarized [13C,15N2]Urea MRI in Healthy Volunteers

Parimal Pravin Joshi1,2, David Shin3, Robert A Bok1, Daniel B Vigneron1,2, Jeremy W Gordon1,2, and Yaewon Kim1
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2UC Berkeley-UCSF Bioengineering Program, UCSF, San Francisco, CA, United States, 3Global MR Applications & Workflow, GE HealthCare, Menlo Park, CA, United States

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas), Contrast Mechanisms

Motivation: Understanding brain perfusion is crucial for assessing several neuropathology and treatment responses.

Goal(s): With the help of 4 healthy subjects, this study investigated an approach by combining ASL with hyperpolarized 13C-urea MRI, aimed at providing complementary brain perfusion assessments, capturing arterial, venous, and tissue perfusion information for enhanced brain vasculature imaging.

Approach: Dynamic urea imaging data were analyzed for arterial and venous flow, while ASL measurements provided tissue perfusion assessments.

Results: This novel study successfully imaged tissue perfusion along with arterial and venous perfusion, validating the combined approach's efficacy in enhancing vascular insights and providing a detailed cerebral perfusion profile.

Impact: The combined hyperpolarized [13C,15N2]urea and ASL MRI can provide a multifaceted assessment of brain arterial flow, venous drainage, and tissue perfusion that may enhance diagnostic capabilities and evaluation in clinical settings.

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Keywords