Abstract #0310

Continuous-time random walk and amide proton transfer-weighted imaging to predict lymphovascular space invasion in non-small cell lung cancer

Nan Meng¹, Qianqian Chen¹, Xuan Yu¹, Jiayin Pan¹, Xiaoxu Chen¹, Jianmin Yuan², Yang Yang³, Zhe Wang², and Meiyun Wang¹

¹Department of Radiology, Henan Provincial People’s Hospital & Zhengzhou University People’s Hospital, Zhengzhou, China, ²Central Research Institute, United Imaging Healthcare Group, Shanghai, China, ³Beijing United Imaging Research Institute of Intelligent Imaging, United Imaging Healthcare Group, Beijing, China

Synopsis

Keywords: Lung, Cancer, lymphovascular space invasion, continuous-time random walk, positron emission tomography

Motivation: Lymphovascular space invasion (LVSI) is associated with poor outcomes in non-small cell lung cancer (NSCLC).

Goal(s): To investigate whether ¹⁸F-FDG PET, a continuous-time random walk (CTRW) model, amide proton transfer-weighted imaging (APTWI)-based parameters may contribute to the non-invasive assessment of LVSI in NSCLC.

Approach: A total of 78 LVSI-positive and 52 LVSI-negative NSCLC patients underwent chest multiparametric ¹⁸F-FDG PET/MRI.

Results: The SUV_max and MTRasym(3.5ppm) were higher, while the ADC, α, β, and D_m were lower in the LVSI-positive group than in the LVSI-negative group. SUV_max, α, β, D_m, and MTRasym(3.5ppm) were independently associated with LVSI positivity.

Impact: The analysis of tumour glucose metabolism, water molecule diffusion, temporal / spatial heterogeneities, and mobile proteins / peptides measurement at multiparametric 18F-FDG PET/MRI enables the prediction of LVSI in NSCLC.

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