Keywords: Diffusion Acquisition, Diffusion Acquisition, Local gradient coils
Motivation: Diffusion-weighted MRI (DWI) and apparent exchange rate (AXR) measurements offer potential for early breast cancer detection but face challenges regarding signal-to-noise ratio (SNR) and physiological-nerve-stimulation limits. Ultra-high gradient amplitudes can improve DWI by reducing echo times and allowing to better sample the DWI parameter space.
Goal(s): To demonstrate the application of a high-amplitude local gradient breast coil (Gmax>1500$$$\;\text{mT/m}$$$) for AXR measurements using short gradient pulses.
Approach: AXR imaging experiments with yeast cell phantoms were performed using short gradient durations.
Results: Experiments showed consistent AXR values across gradient durations. Effects of gradient inhomogeneities on ADC and AXR measurements were successfully compensated.
Impact: The local gradient breast coil enabled AXR measurements with reduced echo times by utilizing extreme gradient amplitudes and slew rates, demonstrating the potential of the coil to increase SNR, extend DWI parameter space coverage and thereby improve breast cancer imaging.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords