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Abstract #0314

Scan-Rescan Repeatability of Axon Diameter Mapping Metrics from Ultra-High-Gradient Diffusion MRI on the Connectome 2.0 Scanner

Laleh Eskandarian1,2, Yixin MA1,3, Hansol Lee1,3, Kwok-Shing Chan1,3, Aneri Bhatt1, Julianna Gerold1, and Susie Y. Huang1,3
1Mass General Hospital, Boston, MA, United States, 2Athinoula A. Martinos Center, Boston, MA, United States, 3Harvard Medical School, Boston, MA, United States

Synopsis

Keywords: Diffusion Analysis & Visualization, White Matter

Motivation: Enhancing MRI reliability improves understanding of brain microstructure and disorders

Goal(s): This study aims to evaluate the reliability and repeatability of ultra-high-gradient diffusion MRI metrics, specifically focusing on the axon diameter index and restricted volume fraction.

Approach: Using a 3T Connectome2.0 scanner, five healthy adults participated in two scanning sessions to assess the scan-rescan reliability of axonal microstructural metrics.

Results: The findings revealed high correlation coefficients for fractional anisotropy and restricted volume fraction (r=0.96), with the axon diameter index showing improved correlation compared to the original Connectome scanner. These results confirm that ultra-high-gradient diffusion MRI provides robust scan-rescan reliability for assessing axonal microstructure.

Impact: This research enhances the understanding of diffusion-MRI metrics' reliability, enabling more accurate studies of brain microstructure. It supports further investigation into neurobiological differences across populations and potential clinical applications.

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Keywords