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Abstract #0315

Undercooked PASTA: Tractometry at low field and low SAR

James Gholam1, Joshua Ametepe1, Neale Wiley2, Shannon Kolind3, Sharada Balaji2, Francesco Padormo4, Mara Cercignani1, and Derek K Jones1
1CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom, 2Physics, University of British Columbia, Vancouver, BC, Canada, 3Medicine (Neurology), University of British Columbia, Vancouver, BC, Canada, 4Hyperfine Inc., Guilford, CT, United States

Synopsis

Keywords: Tractography, Low-Field MRI

Motivation: Tractography affords advantage over volumetric segmentation as it separates areas of otherwise homogeneous contrast based on microstructural measures. Tract-based parameter mapping performed at ultra-low-field extends the utility of parametric maps to isolate functional regions, permitting quantitative studies in otherwise unscanned populations

Goal(s): We sought to implement a feasible tractometry scheme investigating multiple contrasts on a 0.064T commercial MR system

Approach: Corrected and denoised DWIs alongside quantitative T2 (qT2) maps were collected and processed to produce tract-specific measures of several diffusion parameters and qT2.

Results: Streamline parameter maps were found to agree with literature values of T2, MD and FA in a healthy participant.

Impact: Ultra-low-field MR systems offer unprecedented opportunity to access populations otherwise excluded from scanning by location or means. This work demonstrates that traditional high-field tractometry is possible at 0.064T within a feasible scan duration in healthy adults

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Keywords