Meeting Banner
Abstract #0316

Comparative Evaluation of Third-Order Motion-Compensated DT-CMR Across Cardiac Phases Using an Ultra-High-Performance Clinical Scanner

Ke Wen1,2,3, Pedro F. Ferreira1,2, Rick Wage2, Karl P. Kunze4, Dudley J. Pennell1,2, Andrew D. Scott1,2, and Sonia Nielles-Vallespin1,2
1National Heart and Lung Institute, Imperial College London, London, United Kingdom, 2CMR Unit, Royal Brompton Hospital, London, United Kingdom, 3EPSRC Centre for Doctoral Training in Smart Medical Imaging, King’s College London and Imperial College London, London, United Kingdom, 4MR Research Collaborations, Siemens Healthcare Limited, Camberley, United Kingdom

Synopsis

Keywords: Diffusion Acquisition, Diffusion Acquisition, Motion Compensation, Myocardium, Diffusion Tensor CMR

Motivation: DT-CMR enables characterisations of myocardial dynamics with STEAM sequence. Second-order MCSE (M2-MCSE) was found to be unreliable in diastolic DT-CMR imaging. Third-order MCSE (M3-MCSE) potentially improves motion compensation, but its robustness remains unknown across the cardiac cycle.

Goal(s): Evaluate the performance of M3-MCSE DT-CMR in systole and diastole.

Approach: Compared M3-MCSE, M2-MCSE, and STEAM DT-CMR data in systole and diastole on 20 healthy volunteers (HVs) and ADCs across various TDs within diastasis on 5 HVs.

Results: M3-MCSE data quality was lowered due to prolonged TE but worked at a similar diastolic range compared to M2-MCSE. STEAM had more consistent data quality across volunteers.

Impact: We conducted the first in-human evaluation of M3-MCSE for diastolic imaging, comparing it with STEAM and M2-MCSE across various cardiac phases. Findings suggest the importance of further optimising higher-order motion compensation with shorter TE to enhance MCSE clinical potential.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords