Keywords: Diffusion Analysis & Visualization, Microstructure, Image Quality Transfer
Motivation: Diffusion-weighted imaging (DWI) is a powerful technique for investigating brain microstructure and obtaining quantitative measures of microstructural features. However, current resolution limits biological accuracy.
Goal(s): Image Quality Transfer (IQT) was adapted to use spherical harmonics coefficients to enhance DWI resolution acquired with ultra-high b-values and multiple diffusion times.
Approach: IQT performance was assessed in two DWI acquisitions, then enhanced-resolution DWI-data was fitted with advanced biophysical models to demonstrate the impact of resolution enhancement, alongside quantitative and histological accuracy.
Results: IQT reconstructed with high accuracy enhanced-resolution DWI-data, whose fitting provided quantitative and histological accurate maps, highlighting IQT benefits for research and clinical applications.
Impact: We demonstrated IQT effectiveness in advanced DWI acquisitions with ultra-high b-values and multiple diffusion times when adapted with suitable signal representation. This approach advances the precise study of brain microstructure, overcoming current DWI limitations in both clinical and research settings.
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