Abstract #0322

High Resolution Diffusion MRI Tractography in the in-vivo & ex-vivo NHP brain using a human 10.5T scanner

Shaun Warrington¹, Benjamin C. Tendler², Mohamed Kotb Selim¹, Wenchuan Wu², Hamza Farooq³, Steen Moeller³, Pramod Pisharady³, Edward J. Auerbach³, Gregor Adriany³, Alexander Bratch³, Matt Waks³, Steve Jungst³, Noam Harel³, Franco Pestilli⁴, Sarah Heilbronner^3,5, Essa Yacoub³, Kamil Ugurbil³, Christophe Lenglet³, Karla Miller², Saad Jbabdi², Jan Zimmermann^3,6, and Stamatios Sotiropoulos¹

¹Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, UK, Nottingham, United Kingdom, ²Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, UK, Oxford, United Kingdom, ³Centre for Magnetic Resonance Research, University of Minnesota-Twin Cities, MN, USA, Minnesota, MN, United States, ⁴Department of Psychology, Department of Neuroscience, Center for Perceptual Systems, Center for Learning and Memory, The University of Texas at Austin, Austin, Texas, USA, Austin, TX, United States, ⁵Baylor College of Medicine, TX, USA, Texas, TX, United States, ⁶Department of Neuroscience, University of Minnesota, MN, USA., Minnesota, MN, United States

Synopsis

Keywords: Diffusion Acquisition, High-Field MRI, Non-human Primate; 10.5T; Tractography; SSFP

Motivation: High-resolution diffusion MRI (dMRI) at ultra-high field is challenging due to a shorter T2 and increased susceptibility-induced distortions.

Goal(s): To demonstrate the feasibility of high-resolution in-vivo and ex-vivo dMRI, and tractography using the 10.5T whole-body human scanner at CMRR-Minnesota.

Approach: We explored acquisition and processing approaches for pushing resolution towards the mesoscale in the non-human primate (macaque) brain, based on pulsed-gradient spin-echo (in-vivo) and diffusion-weighted steady-state free-precession (ex-vivo).

Results: We showcase high-resolution dMRI datasets (0.75 mm in-vivo, 0.4 mm ex-vivo) of the macaque brain at 10.5T and we propose a pipeline from image reconstruction to biophysical modelling that enables high-resolution tractography reconstructions.

Impact: We showcase for the first time the performance of the 10.5T human whole-body MRI scanner at the CMRR, University of Minnesota, for high-resolution diffusion MRI and tractography in the in-vivo and ex-vivo macaque brain.

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