Abstract #0356

Quantification of myocardial oxygen consumption and myocardial external efficiency using cardiac MRI: a pilot study in post-MI HFrEF patients

Li-Ting Huang^1,2, Henghui Zhang³, Ranran Zhang³, Chia-Chi Yang², Hao Ho⁴, Archana Malagi², Yuheng Huang⁵, Xinqi Li², Jeremy Zepeda², Ghazal Yoosefian², Xinheng Zhang², Janet Wei², Alan C Kwan², Michael D Nelson⁶, Xiaoming Bi⁷, Anthony Christodoulou^4,8, Noel Bairey Merz², Debiao Li², Rohan Dharmakumar⁵, Guan Wang³, and Hsin-jung Yang²

¹National Cheng Kung University Hospital, Tinan, Taiwan, ²Cedars-Sinai Medical Center, Los Angeles, CA, United States, ³The First Hospital of China Medical University, Shenyang, China, ⁴University of California at Los Angeles, Los Angeles, CA, United States, ⁵Krannert Cardiovascular Research Center, Bloomington, IN, United States, ⁶The University of Texas at Arlington, Arlington, TX, United States, ⁷Siemens Medical Solutions USA, Inc., Los Angeles, CA, United States, ⁸Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States

Synopsis

Keywords: Heart Failure, Heart Failure, myocardial infarction, myocardial external efficiency

Motivation: Myocardial external efficiency (MEE) relating the left ventricular (LV) mechanical energetic output to myocardial oxidative metabolism demonstrates the efficiency of LV performance.

Goal(s): Explore the feasibility of a newly developed non-invasive and radiation-free cardiac magnetic resonance (CMR) technique for MEE in patients with heart failure (HF) following myocardial infarction (MI).

Approach: A prospective single institutional study enrolling post-MI HF patients and control subjects who received a high-resolution, non-ECG gated and free-breathing GRE T2-weighted inversion recovery MR oximetry sequence.

Results: MEE derived by CMR demonstrated moderate correlations between EF and myocardial strain and was lower in patients compared to control subjects.

Impact: The non-invasive and radiation-free GRE T2-weighted inversion recovery CMR technique can evaluate myocardial oxidative embolism and assess myocardial performance efficiency, which is lower in post-MI HF patients.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.