Abstract #0357

3D joint bright blood and black blood imaging technique for multi-parametric imaging of carotid artery: feasibility and clinical application

Ning Xu¹, Huiyu Qiao², Shuo Chen¹, Ziming Xu¹, Zihan Ning^1,3, Shuwan Yu¹, and Xihai Zhao¹

¹Biomedical engineering, Center for Biomedical Imaging Research, School of biomedical engineering, Tsinghua Univeristy, Beijing, China, ²Biomedical engineering, School of Biomedical Engineering, Capital Medical University, Beijing, China, ³Imaging physics and engineering research department, Imaging physics and engineering research department, School of Biomedical Engineering and Imaging Sciences, Kings College London, London, United Kingdom

Synopsis

Keywords: Vascular/Vessel Wall, Atherosclerosis

Motivation: Bright blood images can clearly depict CA, further guaranteeing the accuracy of quantitative value. Black and bright blood imaging based multi-contrast imaging and multi-parametric imaging can comprehensively characterize vulnerable plaques.

Goal(s): This study aims to develop a joint bright and black blood imaging technique for T1, T2 and T2* estimation.

Approach: VFA, ViMSDE and VTE mapping framework was optimized to generate varying T1, T2 and T2* contrast as well as different blood and vessel wall contrasts.

Results: Great agreement was achieved in phantom and volunteer study. Plaque components exhibited distinctive signal characteristics and quantitative values in clinical study, indicating its potential clinical application.

Impact: This work provides a potential qualitative and quantitative carotid artery imaging technique from multi-contrast imaging to multi-paramertic imaging, abundant information can be derived from this set of images.

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