Abstract #0358

Reduced CMR right/left ventricular blood pool T2 ratio indicates cognitive impairment in heart failure

Yadong Cui¹, Chong Zheng¹, Shanshan Gu¹, Jin Si², Keling Xiao², Yujie Hu³, Yang Yang⁴, Jing Li², and Jie Lu¹

¹Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China, ²Department of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China, ³Central Research Institute, United Imaging Healthcare Group, Shanghai, China, ⁴Beijing United Imaging Research Institute of Intelligent Imaging, Beijing, China

Synopsis

Keywords: Heart Failure, Quantitative Imaging, Cardiac magnetic resonance, T2 mapping, Cognitive impairment, Hypoxia

Motivation: Systemic hypoxia is considered as a contributor to cognitive impairment in patients with heart failure (HF). Right/left ventricular blood pool T2 ratio (RV/LV T2 ratio) is a novel MRI biomarker of the blood oxygen saturation difference between RV and LV.

Goal(s): We investigated the relationship between RV/LV T2 ratio and cognitive performance in HF patients.

Approach: RV/LV T2 ratio, cardiac function, and cognitive performance were evaluated.

Results: RV/LV T2 ratio partially mediated the correlation between stroke volume and cognitive performance, and it is a valuable indicator for assessment of cognitive impairment in HF patients.

Impact: Right/left ventricular blood pool T2 ratio is a complementary index of venous and arterial blood oxygenation difference based on routine T2 mapping and may serve as a simple and noninvasive indicator for cognitive impairment in patients with heart failure.

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