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Abstract #0405

Subject-specific Dose of Ferumoxytol for Vascular Suppression in Brachial Plexus Magnetic Resonance Neurography

Allison Sydney Lowe1, Shayna Ellie Turbin1, Darryl Sneag1, Mylinh Duong2, and Ek Tsoon Tan1
1Radiology and Imaging, Hospital for Special Surgery, New York, NY, United States, 2Pharmacy, Hospital for Special Surgery, New York, NY, United States

Synopsis

Keywords: Neurography, Contrast Agents, MR Neurography, USPIO

Motivation: Ferumoxytol effectively suppresses vasculature in MR neurography, but the optimal dose is unknown.

Goal(s): To determine the optimal dose by weight and blood volume.

Approach: Thirty-two subjects were infused with varying Ferumoxytol doses (30 to 255 mg Fe) and underwent MR neurography at 3-Tesla; the vessel-to-muscle contrast ratio (CR) was measured.

Results: Logarithmic regression improved with weight-based and volume-based doses (R²=0.443 to 0.613) versus the absolute dose (R²=0.362 to 0.499). 1.75-1.92 mg Fe/kg or 26.9-29.5 mg Fe/L doses were required to obtain CR<0.2, demonstrating that the subject weight/blood volume should be considered to optimize Ferumoxytol-based vascular suppression.

Impact: Subject weight- or blood-volume-specific Ferumoxytol doses may provide effective vascular suppression for MR neurography evaluation of peripheral neuropathies like Parsonage Turner Syndrome (PTS), to reduce the dose and infusion time required.

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