Keywords: Liver, Relaxometry, Fat Fraction, Iron Particle Size
Motivation: Iron particle sizes can influence microscopic magnetic field heterogeneities, affecting R2* decay.
Goal(s): To investigate the impact of iron particle size on R2* and fat fraction (FF) estimations for coexisting hepatic iron overload and steatosis.
Approach: Impact of iron particle sizes (0.38, 0.52, and 0.71 µm) was analyzed using Monte Carlo simulations and fat-iron phantoms with varying iron content and FF. Three-way ANOVA assessed the impact of iron particle size on R2* and FF estimations.
Results: R2* and FF estimations are affected by iron particle size, with smaller particles causing higher R2* values and increased FF estimation bias.
Impact: In the concomitant presence of fat and iron, the size of iron particles can affect the accuracy of fat fraction and R2* estimations, and hence may cause bias in the assessment of hepatic iron overload and steatosis using MRI.
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