Keywords: Pancreas, Pancreas, Fat quantification, Diabetes
Motivation: Pancreatic fat accumulation is critical in the pathogenesis of type 2 diabetes mellitus (T2DM), yet accurate in vivo measurement remains challenging.
Goal(s): To quantify pancreatic fat using the IDEALIQ method and assess its predictive value for impaired glucose tolerance (IGT) and T2DM.
Approach: We employed IDEALIQ to non-invasively measure pancreatic fat volume fraction (PFVF) in T2DM, IGT, and normal glucose tolerance (NGT) groups, correlating the results with clinical metrics.
Results: PFVF was significantly higher in the T2DM group. Logistic regression confirmed PFVF as a strong independent predictor of IGT and T2DM, with an AUC of 0.871, sensitivity of 92.7%, and specificity of 71.7%.
Impact: This study presents a non-invasive method to quantify pancreatic fat, enhancing early detection and risk prediction for impaired glucose tolerance and type 2 diabetes, and offering new insights into pancreatic fat’s role in insulin resistance and diabetes progression.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords