Keywords: Biology, Models, Methods, Perfusion
Motivation: Non-invasive non-contrast liver assessment is vital for patients who cannot use contrast agents. Non-contrast ASL assessment to separate hepatic artery (HA) and portal vein (PV) perfusion in the liver is clinically important.
Goal(s): To optimize non-contrast ASL for liver perfusion, addressing motion artifacts and HA/PV separation.
Approach: Free-breathing HA and PV selective labeling is performed multiple TI times.
Results: The study identifies two distinct blood flow patterns: early sharp HA perfusion and slow broad PV perfusion. Initial results demonstrate the potential for quantitative perfusion measurement and the possibility of diagnosing liver disease.
Impact: Current methods like dynamic contrast-enhancement require the use of contrast agents to measure arterial and portal blood flow. We propose a novel non-invasive non-contrast alternative, enabling separate assessments of HA and PV perfusion, making liver diagnostics safer and more accessible.
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