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Abstract #0419

Hepatic artery and portal vein selective non-contrast MR perfusion in the liver

Yoshiki Kuwatsuru1,2, Vadim Malis1, Yoshimori Kassai3, Claude Sirlin1, and Mitsue Miyazaki1
1Radiology, University of California, San Diego, La Jolla, CA, United States, 2Radiology, Juntendo Univercity, Tokyo, Japan, 3Canon Medical Systems Corp., Tochigi, Japan

Synopsis

Keywords: Biology, Models, Methods, Perfusion

Motivation: Non-invasive non-contrast liver assessment is vital for patients who cannot use contrast agents. Non-contrast ASL assessment to separate hepatic artery (HA) and portal vein (PV) perfusion in the liver is clinically important.

Goal(s): To optimize non-contrast ASL for liver perfusion, addressing motion artifacts and HA/PV separation.

Approach: Free-breathing HA and PV selective labeling is performed multiple TI times.

Results: The study identifies two distinct blood flow patterns: early sharp HA perfusion and slow broad PV perfusion. Initial results demonstrate the potential for quantitative perfusion measurement and the possibility of diagnosing liver disease.

Impact: Current methods like dynamic contrast-enhancement require the use of contrast agents to measure arterial and portal blood flow. We propose a novel non-invasive non-contrast alternative, enabling separate assessments of HA and PV perfusion, making liver diagnostics safer and more accessible.

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Keywords