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Abstract #0420

Multiparametric 3D Vector Magnetic Resonance Elastography Reveals Hepatic Biphasic Mechanical Properties in Rat Models of Portal Hypertension

Caixin Qiu1, Peng xu1, Hao Wu1, Jiahui Li1, Nana Owusu1, Kevin Glaser1, Usman Yaqoob2, Vijay Shah2, Armando Manduca1, Richard Ehman1, and Meng Yin1
1Radiology, Mayo Clinic, Rochester, MN, United States, 2Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States

Synopsis

Keywords: Biomarkers, Elastography, Magnetic resonance elastography, Biphasic mechanical properties, Portal hypertension, Rat model

Motivation: Magnetic resonance elastography (MRE)-assessed viscoelastic parameters can differentiate the fluid and solid phases of liver tissue, potentially serving as an imaging biomarker for fluid pressure-related pathology

Goal(s): To explore the role of multiparametric 3D MRE techniques in characterizing biphasic mechanical properties in rats with portal hypertension (PHTN)

Approach: Multiparametric dual-frequency 3D MRE was used to evaluate the biphasic mechanical properties of the liver in a PHTN rat model

Results: Liver stiffness (LS) and loss modulus (LM) were both correlated with portal pressure. LS had the best correlation with the fibrosis extent (r =0.770), while LM with the interstitial fluid pressure (r =0.479).

Impact: Advanced MRE assessment of tissue mechanical properties offer novel imaging biomarkers for fluid pressure-related pathological processes. This approach promising approach for evaluating new therapeutic interventions for portal hypertension.

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