Keywords: Biomarkers, Elastography, Magnetic resonance elastography, Biphasic mechanical properties, Portal hypertension, Rat model
Motivation: Magnetic resonance elastography (MRE)-assessed viscoelastic parameters can differentiate the fluid and solid phases of liver tissue, potentially serving as an imaging biomarker for fluid pressure-related pathology
Goal(s): To explore the role of multiparametric 3D MRE techniques in characterizing biphasic mechanical properties in rats with portal hypertension (PHTN)
Approach: Multiparametric dual-frequency 3D MRE was used to evaluate the biphasic mechanical properties of the liver in a PHTN rat model
Results: Liver stiffness (LS) and loss modulus (LM) were both correlated with portal pressure. LS had the best correlation with the fibrosis extent (r =0.770), while LM with the interstitial fluid pressure (r =0.479).
Impact: Advanced MRE assessment of tissue mechanical properties offer novel imaging biomarkers for fluid pressure-related pathological processes. This approach promising approach for evaluating new therapeutic interventions for portal hypertension.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords