Abstract #0423

Diagnosing Intramyocardial Hemorrhage using Free-Breathing, Cardiac QSM with Full LV Coverage: Clinical Findings with Validations in Canines

Yuheng Huang^1,2, Xin Liu³, xingmin Guan¹, Xinheng Zhang^1,4, Gregory Anthony¹, Archana Malagi⁵, Chia-chi Yang⁵, Li-Ting Huang⁵, Xinqi Li⁵, Ghazal Yoosefian¹, Xiaoming Bi⁶, Fei Han⁶, Chang Gao⁶, Kim-Lien Nguyen⁷, Debiao Li⁵, Qi Yang³, Rohan Dharmakumar¹, and Hsin-Jung Yang⁵

¹krannert cardiovascular research center, Indiana University School of Medicine, Indianapolis, IN, United States, ²Bioengineering, UCLA, LA, CA, United States, ³Beijing Chaoyang Hospiotal, Capital Medical University, Beijing, China, ⁴Biomedical Imaging Research Institute, Cedars Sinai Medical Center, LA, CA, United States, ⁵Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, LA, CA, United States, ⁶Siemens Healthineers, LA, LA, United States, ⁷David Geffen School of Medicine, UCLA, LA, CA, United States

Synopsis

Keywords: Myocardium, Cardiovascular, Quantitative Susceptibility Mapping (QSM); Intramyocardial Hemorrhage; Iron Imaging

Motivation: Accurate detection and quantification of intramyocardial hemorrhage (IMH) in reperfused myocardial infarction (MI) is crucial for patient management.

Goal(s): However, current standard IMH imaging techniques (e.g., breath-hold T2* or 3D R2* maps) pose multiple technical challenges with imaging artifacts and confounders.

Approach: This study presents a free-breathing cardiac high-dynamic-range quantitative susceptibility mapping (HDR-QSM) technique to improve IMH detection and quantification over conventional iron-sensitive MRI.

Results: Proposed method is tested in animal models and MI patients, which show that HDR-QSM can significantly reduce imaging artifacts, improve accuracy in detection of hMI and quantification of iron quantification within hMI compared to existing standards.

Impact: The free-breathing HDR-QSM technique enhances IMH detection and quantification over R2* mapping. It is validated in animals and tested in STEMI patients with impaired breath-holding ability and shows promise for broader clinical use, pending further validation in larger trials.

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